[2603.25322] AD-CARE: A Guideline-grounded, Modality-agnostic LLM Agent for Real-world Alzheimer's Disease Diagnosis with Multi-cohort Assessment, Fairness Analysis, and Reader Study

Computer Science > Multiagent Systems arXiv:2603.25322 (cs) [Submitted on 26 Mar 2026] Title:AD-CARE: A Guideline-grounded, Modality-agnostic LLM Agent for Real-world Alzheimer's Disease Diagnosis with Multi-cohort Assessment, Fairness Analysis, and Reader Study Authors:Wenlong Hou, Sheng Bi, Guangqian Yang, Lihao Liu, Ye Du, Hanxiao Xue, Juncheng Wang, Yuxiang Feng, Yue Xun, Nanxi Yu, Ning Mao, Mo Yang, Yi Wah Eva Cheung, Ling Long, Kay Chen Tan, Lequan Yu, Xiaomeng Ma, Shaozhen Yan, Shujun Wang View a PDF of the paper titled AD-CARE: A Guideline-grounded, Modality-agnostic LLM Agent for Real-world Alzheimer's Disease Diagnosis with Multi-cohort Assessment, Fairness Analysis, and Reader Study, by Wenlong Hou and 18 other authors View PDF HTML (experimental) Abstract:Alzheimer's disease (AD) is a growing global health challenge as populations age, and timely, accurate diagnosis is essential to reduce individual and societal burden. However, real-world AD assessment is hampered by incomplete, heterogeneous multimodal data and variability across sites and patient demographics. Although large language models (LLMs) have shown promise in biomedicine, their use in AD has largely been confined to answering narrow, disease-specific questions rather than generating comprehensive diagnostic reports that support clinical decision-making. Here we expand LLM capabilities for clinical decision support by introducing AD-CARE, a modality-agnostic agent that performs guideline-grounded di...